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The synthesis of a (99m)Tc-labeled tetravalent targeting probe upon isonitrile coordination to (99m)Tc(I) for enhanced target uptake in saturable systems
The presence of excess unlabeled ligands in the injectate hinders the target uptake of (99m)Tc-labeled targeting vectors. To address the issue, we previously developed a chemical design which provides a (99m)Tc-labeled trivalent RGD probe upon CN-βAla-Gly-Gly-c(RGDfK) (L(β)) coordination to [(99m)Tc...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070385/ https://www.ncbi.nlm.nih.gov/pubmed/35531015 http://dx.doi.org/10.1039/c9ra04311j |