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Fast in-vitro screening of FLT3-ITD inhibitors using silkworm-baculovirus protein expression system
We report expression and purification of a FLT3 protein with ITD mutation (FLT3-ITD) with a steady tyrosine kinase activity using a silkworm-baculovirus system, and its application as a fast screening system of tyrosine kinase inhibitors. The FLT3-ITD protein was expressed in Bombyx mori L. pupae in...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070948/ https://www.ncbi.nlm.nih.gov/pubmed/35511790 http://dx.doi.org/10.1371/journal.pone.0261699 |