A novel in vitro 3D model of the human bone marrow to bridge the gap between in vitro and in vivo genotoxicity testing

The regulatory 2D in vitro micronucleus (MN) assay is part of a battery of tests, used to test for genotoxicity of new and existing compounds before they are assessed in vivo (ICH S2). The 2D MN assay consists of a monolayer of cells, whereas the in vivo bone marrow (BM) setting comprises a multicel...

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Detalles Bibliográficos
Autores principales: Vernon, Alexander R, Pemberton, Roy M, Morse, H Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Manuscripts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071074/
https://www.ncbi.nlm.nih.gov/pubmed/35394550
http://dx.doi.org/10.1093/mutage/geac009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071074/
https://www.ncbi.nlm.nih.gov/pubmed/35394550
http://dx.doi.org/10.1093/mutage/geac009

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