1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a novel difluoroalkylating reagent for 1,1-difluoroethylation of arylboronic acids

1,1-Difluoroethylated aromatics are of great importance in medicinal chemistry and related fields. 1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a cheap and abundant industrial raw material, is viewed as an ideal 1,1-difluoroethylating reagent, but the direct introduction of the difluoroethyl (CF(2)CH(...

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Detalles Bibliográficos
Autores principales: Liu, Jianchang, Zhang, Jida, Wu, Chaolin, Liu, Hefu, Liu, Hui, Sun, Fenggang, Li, Yueyun, Liu, Yuying, Dong, Yunhui, Li, Xinjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071211/
https://www.ncbi.nlm.nih.gov/pubmed/35529618
http://dx.doi.org/10.1039/c9ra06406k
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author Liu, Jianchang
Zhang, Jida
Wu, Chaolin
Liu, Hefu
Liu, Hui
Sun, Fenggang
Li, Yueyun
Liu, Yuying
Dong, Yunhui
Li, Xinjin
author_facet Liu, Jianchang
Zhang, Jida
Wu, Chaolin
Liu, Hefu
Liu, Hui
Sun, Fenggang
Li, Yueyun
Liu, Yuying
Dong, Yunhui
Li, Xinjin
author_sort Liu, Jianchang
collection PubMed
description 1,1-Difluoroethylated aromatics are of great importance in medicinal chemistry and related fields. 1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a cheap and abundant industrial raw material, is viewed as an ideal 1,1-difluoroethylating reagent, but the direct introduction of the difluoroethyl (CF(2)CH(3)) group onto aromatic rings using CH(3)CF(2)Cl has not been successfully accomplished. Herein, we disclose a nickel-catalyzed 1,1-difluoroethylation of arylboronic acids with CH(3)CF(2)Cl for the synthesis of (1,1-difluoroethyl)arenes.
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spelling pubmed-90712112022-05-06 1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a novel difluoroalkylating reagent for 1,1-difluoroethylation of arylboronic acids Liu, Jianchang Zhang, Jida Wu, Chaolin Liu, Hefu Liu, Hui Sun, Fenggang Li, Yueyun Liu, Yuying Dong, Yunhui Li, Xinjin RSC Adv Chemistry 1,1-Difluoroethylated aromatics are of great importance in medicinal chemistry and related fields. 1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a cheap and abundant industrial raw material, is viewed as an ideal 1,1-difluoroethylating reagent, but the direct introduction of the difluoroethyl (CF(2)CH(3)) group onto aromatic rings using CH(3)CF(2)Cl has not been successfully accomplished. Herein, we disclose a nickel-catalyzed 1,1-difluoroethylation of arylboronic acids with CH(3)CF(2)Cl for the synthesis of (1,1-difluoroethyl)arenes. The Royal Society of Chemistry 2019-09-09 /pmc/articles/PMC9071211/ /pubmed/35529618 http://dx.doi.org/10.1039/c9ra06406k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Liu, Jianchang
Zhang, Jida
Wu, Chaolin
Liu, Hefu
Liu, Hui
Sun, Fenggang
Li, Yueyun
Liu, Yuying
Dong, Yunhui
Li, Xinjin
1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a novel difluoroalkylating reagent for 1,1-difluoroethylation of arylboronic acids
title 1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a novel difluoroalkylating reagent for 1,1-difluoroethylation of arylboronic acids
title_full 1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a novel difluoroalkylating reagent for 1,1-difluoroethylation of arylboronic acids
title_fullStr 1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a novel difluoroalkylating reagent for 1,1-difluoroethylation of arylboronic acids
title_full_unstemmed 1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a novel difluoroalkylating reagent for 1,1-difluoroethylation of arylboronic acids
title_short 1,1-Difluoroethyl chloride (CH(3)CF(2)Cl), a novel difluoroalkylating reagent for 1,1-difluoroethylation of arylboronic acids
title_sort 1,1-difluoroethyl chloride (ch(3)cf(2)cl), a novel difluoroalkylating reagent for 1,1-difluoroethylation of arylboronic acids
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071211/
https://www.ncbi.nlm.nih.gov/pubmed/35529618
http://dx.doi.org/10.1039/c9ra06406k
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