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Are we leaving money on the table in infertility RCTs? Trialists should statistically adjust for prespecified, prognostic covariates to increase power

Infertility randomized controlled trials (RCTs) are often too small to detect realistic treatment effects. Large observational studies have been proposed as a solution. However, this strategy threatens to weaken the evidence base further, because non-random assignment to treatments makes it impossib...

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Detalles Bibliográficos
Autores principales: Wilkinson, J, Showell, M, Taxiarchi, V P, Lensen, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071217/
https://www.ncbi.nlm.nih.gov/pubmed/35199145
http://dx.doi.org/10.1093/humrep/deac030