Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9

While screening our in-house 1072 marketed drugs for their ability to extend the lifespan using Caenorhabditis elegans (C. elegans) as an animal model, crotamiton (N-ethyl-o-crotonotoluidide) showed anti-aging activity and was selected for further structural optimization. After replacing the ortho-m...

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Detalles Bibliográficos
Autores principales: Bao, Keting, Liu, Wenwen, Song, Zhouzhi, Feng, Jiali, Mao, Zhifan, Bao, Lingyuan, Sun, Tianyue, Hu, Zelan, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071264/
https://www.ncbi.nlm.nih.gov/pubmed/35510610
http://dx.doi.org/10.7554/eLife.72410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071264/
https://www.ncbi.nlm.nih.gov/pubmed/35510610
http://dx.doi.org/10.7554/eLife.72410

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