A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels

Resurgent currents (I(NaR)) produced by voltage-gated sodium channels are required for many neurons to maintain high-frequency firing and contribute to neuronal hyperexcitability and disease pathophysiology. Here, we show, for the first time, that I(NaR) can be reconstituted in a heterologous system...

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Detalles Bibliográficos
Autores principales: Xiao, Yucheng, Theile, Jonathan W, Zybura, Agnes, Pan, Yanling, Lin, Zhixin, Cummins, Theodore R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071269/
https://www.ncbi.nlm.nih.gov/pubmed/35441593
http://dx.doi.org/10.7554/eLife.77558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071269/
https://www.ncbi.nlm.nih.gov/pubmed/35441593
http://dx.doi.org/10.7554/eLife.77558

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