RNA marker modifications reveal the necessity for rigorous preparation protocols to avoid artifacts in epitranscriptomic analysis

The accurate definition of an epitranscriptome is endangered by artefacts resulting from RNA degradation after cell death, a ubiquitous yet little investigated process. By tracing RNA marker modifications through tissue preparation protocols, we identified a major blind spot from daily lab routine,...

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Detalles Bibliográficos
Autores principales: Richter, Florian, Plehn, Johanna E, Bessler, Larissa, Hertler, Jasmin, Jörg, Marko, Cirzi, Cansu, Tuorto, Francesca, Friedland, Kristina, Helm, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071408/
https://www.ncbi.nlm.nih.gov/pubmed/34850949
http://dx.doi.org/10.1093/nar/gkab1150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071408/
https://www.ncbi.nlm.nih.gov/pubmed/34850949
http://dx.doi.org/10.1093/nar/gkab1150

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