Cargando…

Guanine quadruplexes in the RNA genome of the tick-borne encephalitis virus: their role as a new antiviral target and in virus biology

We have identified seven putative guanine quadruplexes (G4) in the RNA genome of tick-borne encephalitis virus (TBEV), a flavivirus causing thousands of human infections and numerous deaths every year. The formation of G4s was confirmed by biophysical methods on synthetic oligonucleotides derived fr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holoubek, Jiří, Bednářová, Klára, Haviernik, Jan, Huvarová, Ivana, Dvořáková, Zuzana, Černý, Jiří, Outlá, Martina, Salát, Jiří, Konkol'ová, Eva, Boura, Evzen, Růžek, Daniel, Vorlíčková, Michaela, Eyer, Luděk, Renčiuk, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071444/ https://www.ncbi.nlm.nih.gov/pubmed/35420134 http://dx.doi.org/10.1093/nar/gkac225

Ejemplares similares

Diversity of Parallel Guanine Quadruplexes Induced by Guanine Substitutions
por: Bednářová, Klára, et al.
Publicado: (2020)

Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses
por: Štefánik, Michal, et al.
Publicado: (2022)

FDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells
por: Stefanik, Michal, et al.
Publicado: (2020)

Tick-Borne Encephalitis Virus Vaccines Contain Non-Structural Protein 1 Antigen and May Elicit NS1-Specific Antibody Responses in Vaccinated Individuals
por: Salat, Jiri, et al.
Publicado: (2020)

Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication
por: Dejmek, Milan, et al.
Publicado: (2021)

Clustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes
por: Kejnovská, Iva, et al.
Publicado: (2017)

Dynamics of Whole Virus and Non-Structural Protein 1 (NS1) IgG Response in Mice Immunized with Two Commercial Tick-Borne Encephalitis Vaccines
por: Salat, Jiri, et al.
Publicado: (2022)

i-Motif of cytosine-rich human telomere DNA fragments containing natural base lesions
por: Dvořáková, Zuzana, et al.
Publicado: (2018)

A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases
por: Konkolova, Eva, et al.
Publicado: (2022)

Characterisation of Zika virus infection in primary human astrocytes
por: Stefanik, Michal, et al.
Publicado: (2018)

Systematic investigation of sequence requirements for DNA i-motif formation
por: Školáková, Petra, et al.
Publicado: (2019)

Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses
por: Konkolova, Eva, et al.
Publicado: (2020)

Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2
por: Stefanik, Michal, et al.
Publicado: (2021)

Arrangements of human telomere DNA quadruplex in physiologically relevant K(+) solutions
por: Renčiuk, D., et al.
Publicado: (2009)

Arrangements of human telomere DNA quadruplex in physiologically relevant K(+) solutions
por: Renčiuk, D., et al.
Publicado: (2015)

A combination of two resistance mechanisms is critical for tick-borne encephalitis virus escape from a broadly neutralizing human antibody
por: Svoboda, Pavel, et al.
Publicado: (2023)

High-Throughput Fluorescent Assay for Inhibitor Screening of Proteases from RNA Viruses
por: Cihlova, Bara, et al.
Publicado: (2021)

Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells
por: Sirmarova, Jana, et al.
Publicado: (2018)

The structural model of Zika virus RNA-dependent RNA polymerase in complex with RNA for rational design of novel nucleotide inhibitors
por: Šebera, Jakub, et al.
Publicado: (2018)

Changes in cytokine and chemokine profiles in mouse serum and brain, and in human neural cells, upon tick-borne encephalitis virus infection
por: Pokorna Formanova, Petra, et al.
Publicado: (2019)

Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses
por: Haviernik, Jan, et al.
Publicado: (2018)

Electron Tomography Analysis of Tick-Borne Encephalitis Virus Infection in Human Neurons
por: Bílý, Tomáš, et al.
Publicado: (2015)

Structural analysis of the putative SARS-CoV-2 primase complex
por: Konkolova, Eva, et al.
Publicado: (2020)

Breakdown of the Blood-Brain Barrier during Tick-Borne Encephalitis in Mice Is Not Dependent on CD8(+) T-Cells
por: Růžek, Daniel, et al.
Publicado: (2011)

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus
por: Krol, Ewelina, et al.
Publicado: (2019)

Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system
por: Palus, Martin, et al.
Publicado: (2013)

Experimental and Natural Infections of Tick-Borne Encephalitis Virus in Dogs
por: Salat, Jiri, et al.
Publicado: (2021)

Antiviral activity of singlet oxygen-photogenerating perylene compounds against SARS-CoV-2: Interaction with the viral envelope and photodynamic virion inactivation
por: Straková, Petra, et al.
Publicado: (2023)

Tick-Borne Encephalitis in Sheep, Romania
por: Salat, Jiri, et al.
Publicado: (2017)

Complexity of Guanine Quadruplex Unfolding Pathways Revealed by Atomistic Pulling Simulations
por: Stadlbauer, Petr, et al.
Publicado: (2023)

Guanine quadruplexes are formed by specific regions of human transposable elements
por: Lexa, Matej, et al.
Publicado: (2014)

Tick-Borne Encephalitis in an 8.5-Month-Old Boy Suspected of Febrile Seizures
por: Krbková, Lenka, et al.
Publicado: (2021)

Structure of monkeypox virus poxin: implications for drug design
por: Duchoslav, Vojtech, et al.
Publicado: (2023)

Circular dichroism and conformational polymorphism of DNA
por: Kypr, Jaroslav, et al.
Publicado: (2009)

Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine
por: Renciuk, Daniel, et al.
Publicado: (2013)

A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus
por: Palus, Martin, et al.
Publicado: (2018)

Evolution of Tertiary Structure of Viral RNA Dependent Polymerases
por: Černý, Jiří, et al.
Publicado: (2014)

Postindustrial Landscapes Are Neglected Localities That May Play an Important Role in the Urban Ecology of Ticks and Tick-Borne Diseases—A Pilot Study
por: Dvořáková, Anna, et al.
Publicado: (2023)

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
por: Eyer, Luděk, et al.
Publicado: (2018)

Fitness of mCherry Reporter Tick-Borne Encephalitis Virus in Tick Experimental Models
por: Kevély, Ádám, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qime8kj14kd64pe56avtl8td17