The tRNA discriminator base defines the mutual orthogonality of two distinct pyrrolysyl-tRNA synthetase/tRNA(Pyl) pairs in the same organism

Site-specific incorporation of distinct non-canonical amino acids into proteins via genetic code expansion requires mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs. Pyrrolysyl-tRNA synthetase (PylRS)/tRNA(Pyl) pairs are ideal for genetic code expansion and have been extensively engineered f...

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Detalles Bibliográficos
Autores principales: Zhang, Haolin, Gong, Xuemei, Zhao, Qianqian, Mukai, Takahito, Vargas-Rodriguez, Oscar, Zhang, Huiming, Zhang, Yuxing, Wassel, Paul, Amikura, Kazuaki, Maupin-Furlow, Julie, Ren, Yan, Xu, Xun, Wolf, Yuri I, Makarova, Kira S, Koonin, Eugene V, Shen, Yue, Söll, Dieter, Fu, Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071458/
https://www.ncbi.nlm.nih.gov/pubmed/35466371
http://dx.doi.org/10.1093/nar/gkac271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071458/
https://www.ncbi.nlm.nih.gov/pubmed/35466371
http://dx.doi.org/10.1093/nar/gkac271

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