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Psoralen mapping reveals a bacterial genome supercoiling landscape dominated by transcription
DNA supercoiling is a key regulator of all DNA metabolic processes including replication, transcription, and recombination, yet a reliable genomic assay for supercoiling is lacking. Here, we present a robust and flexible method (Psora-seq) to measure whole-genome supercoiling at high resolution. Usi...
Autores principales: | Visser, Bryan J, Sharma, Sonum, Chen, Po J, McMullin, Anna B, Bates, Maia L, Bates, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071471/ https://www.ncbi.nlm.nih.gov/pubmed/35420137 http://dx.doi.org/10.1093/nar/gkac244 |
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