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Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition
Mammalian early epiblasts at different phases are characterized by naïve, formative, and primed pluripotency states, involving extensive transcriptome changes. Here, we report that deadenylase Cnot8 of Ccr4-Not complex plays essential roles during the transition from naïve to formative state. Knock...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071485/ https://www.ncbi.nlm.nih.gov/pubmed/35390160 http://dx.doi.org/10.1093/nar/gkac236 |