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Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition

Mammalian early epiblasts at different phases are characterized by naïve, formative, and primed pluripotency states, involving extensive transcriptome changes. Here, we report that deadenylase Cnot8 of Ccr4-Not complex plays essential roles during the transition from naïve to formative state. Knock...

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Detalles Bibliográficos
Autores principales:	Quan, Yujun, Wang, Meijiao, Xu, Chengpeng, Wang, Xiaoxiao, Wu, Yu, Qin, Dandan, Lin, Yuxuan, Lu, Xukun, Lu, Falong, Li, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071485/ https://www.ncbi.nlm.nih.gov/pubmed/35390160 http://dx.doi.org/10.1093/nar/gkac236

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