Cargando…

Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in Pseudomonas aeruginosa

Bacteria regulate their phenotype, growth and population via a signalling pathway known as quorum sensing. In this process, bacteria produce signalling molecules (autoinducers) to recognize their population density. Inhibiting this quorum sensing signalling pathway is one of the potential methods to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Srinivasarao, Singireddi, Nandikolla, Adinarayana, Nizalapur, Shashidhar, Yu, Tsz Tin, Pulya, Sravani, Ghosh, Balaram, Murugesan, Sankaranarayanan, Kumar, Naresh, Chandra Sekhar, Kondapalli Venkata Gowri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071802/ https://www.ncbi.nlm.nih.gov/pubmed/35528444 http://dx.doi.org/10.1039/c9ra05059k

Ejemplares similares

Synthesis, study of antileishmanial and antitrypanosomal activity of imidazo pyridine fused triazole analogues
por: Nandikolla, Adinarayana, et al.
Publicado: (2020)

Inhibitors of pantothenate synthetase of Mycobacterium tuberculosis – a medicinal chemist perspective
por: Suresh, Amaroju, et al.
Publicado: (2020)

Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents
por: Srinivasarao, Singireddi, et al.
Publicado: (2020)

Correction: Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents
por: Srinivasarao, Singireddi, et al.
Publicado: (2020)

Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives – An update
por: Banoth, Karan Kumar, et al.
Publicado: (2020)

Design, synthesis and biological evaluation of benzo-[d]-imidazo-[2,1-b]-thiazole and imidazo-[2,1-b]-thiazole carboxamide triazole derivatives as antimycobacterial agents
por: Chitti, Surendar, et al.
Publicado: (2022)

N-Acetylglucosamine Inhibits LuxR, LasR and CviR Based Quorum Sensing Regulated Gene Expression Levels
por: Kimyon, Önder, et al.
Publicado: (2016)

Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR
por: Claussen, Anetta, et al.
Publicado: (2013)

Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies
por: Faheem,, et al.
Publicado: (2021)

Reversible Signal Binding by the Pseudomonas aeruginosa Quorum-Sensing Signal Receptor LasR
por: Sappington, Kaia J., et al.
Publicado: (2011)

A New Transcriptional Repressor of the Pseudomonas aeruginosa Quorum Sensing Receptor Gene lasR
por: Longo, Francesca, et al.
Publicado: (2013)

Synthesis and Structure of Sulfur Derivatives from 2-Aminobenzimidazole
por: Cruz, Alejandro, et al.
Publicado: (2014)

Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses
por: LaFayette, Shantelle L., et al.
Publicado: (2015)

LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa
por: Feltner, John B., et al.
Publicado: (2016)

Sulfane Sulfur Regulates LasR-Mediated Quorum Sensing and Virulence in Pseudomonas aeruginosa PAO1
por: Xuan, Guanhua, et al.
Publicado: (2021)

Exemplifying the next generation of antibiotic susceptibility intensifiers of phytochemicals by LasR-mediated quorum sensing inhibition
por: Shukla, Arpit, et al.
Publicado: (2021)

The phage-encoded protein PIT2 impacts Pseudomonas aeruginosa quorum sensing by direct interaction with LasR
por: Schroven, Kaat, et al.
Publicado: (2023)

1,2,3-Triazoles
por: Rachwal, S., et al.
Publicado: (2008)

Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19
por: Faheem, et al.
Publicado: (2020)

2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling
por: Ferreira, Rafael Augusto Alves, et al.
Publicado: (2021)

Microevolution of the mexT and lasR Reinforces the Bias of Quorum Sensing System in Laboratory Strains of Pseudomonas aeruginosa PAO1
por: Liu, Yang, et al.
Publicado: (2022)

In Silico Identification of Natural Food Compounds as Potential Quorum-Sensing Inhibitors Targeting the LasR Receptor of Pseudomonas aeruginosa
por: Magri, Meryam, et al.
Publicado: (2023)

High-Throughput Virtual Screening for a New Class of Antagonist Targeting LasR of Pseudomonas aeruginosa
por: Vetrivel, Aishwarya, et al.
Publicado: (2021)

Sennoside A inhibits quorum sensing system to attenuate its regulated virulence and pathogenicity via targeting LasR in Pseudomonas aeruginosa
por: Han, Xiaofeng, et al.
Publicado: (2022)

1274. Evaluating the Activity of SPR719, a Novel Aminobenzimidazole, against Nontuberculous Mycobacteria
por: Murray, Beverly, et al.
Publicado: (2020)

Anti-Angiogenetic and Anti-Lymphangiogenic Effects of a Novel 2-Aminobenzimidazole Derivative, MFB
por: Hsu, Ming-Jen, et al.
Publicado: (2022)

Derivatives of 2-aminobenzimidazole potentiate ASIC open state with slow kinetics of activation and desensitization
por: Evlanenkov, Konstantin K, et al.
Publicado: (2023)

Study of quorum-sensing LasR and RhlR genes and their dependent virulence factors in Pseudomonas aeruginosa isolates from infected burn wounds
por: Elnegery, Aya Ahmad, et al.
Publicado: (2021)

Design and Synthesis of Lactams Derived from Mucochloric and Mucobromic Acids as Pseudomonas aeruginosa Quorum Sensing Inhibitors
por: Almohaywi, Basmah, et al.
Publicado: (2018)

Chiral 2-Aminobenzimidazole as Bifunctional Catalyst in the Asymmetric Electrophilic Amination of Unprotected 3-Substituted Oxindoles
por: Benavent, Llorenç, et al.
Publicado: (2018)

Design, Synthesis, and Biological Evaluation of Novel Quinazolin-4(3H)-One-Based Histone Deacetylase 6 (HDAC6) Inhibitors for Anticancer Activity
por: Khetmalis, Yogesh Mahadu, et al.
Publicado: (2023)

1,2,3-Triazoles as Biomimetics in Peptide Science
por: Agouram, Naima, et al.
Publicado: (2021)

Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole)
por: Danneberg, Friederike, et al.
Publicado: (2015)

Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks
por: Kwak, Jung Pyo, et al.
Publicado: (2021)

Norlobaridone Inhibits Quorum Sensing-Dependent Biofilm Formation and Some Virulence Factors in Pseudomonas aeruginosa by Disrupting Its Transcriptional Activator Protein LasR Dimerization
por: Soltane, Raya, et al.
Publicado: (2023)

Characterization of lasR-deficient clinical isolates of Pseudomonas aeruginosa
por: Wang, Yao, et al.
Publicado: (2018)

Antimicrobial studies of unsymmetrical bis-1,2,3-triazoles
por: Banday, Abid H, et al.
Publicado: (2012)

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
por: Oueis, Emilia, et al.
Publicado: (2016)

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
por: Oueis, Emilia, et al.
Publicado: (2016)

A practical flow synthesis of 1,2,3-triazoles
por: Drelinkiewicz, Dawid, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_au40bn2eemu9507jv3mgb7mch0