5-Carboxylcytosine is resistant towards phosphodiesterase I digestion: implications for epigenetic modification quantification by mass spectrometry

DNA cytosine modifications are important epigenetic modifications in gene regulation and pathogenesis. DNA hydrolysis followed by HPLC-MS/MS is the gold standard in DNA modification quantification. In particular, it is the only sensitive and accurate method for low abundance modifications, such as 5...

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Detalles Bibliográficos
Autores principales: Yuan, Fang, Bi, Ying, Zhang, Jia-Yuan, Zhou, Ying-Lin, Zhang, Xin-Xiang, Song, Chun-Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071843/
https://www.ncbi.nlm.nih.gov/pubmed/35528408
http://dx.doi.org/10.1039/c9ra04375f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071843/
https://www.ncbi.nlm.nih.gov/pubmed/35528408
http://dx.doi.org/10.1039/c9ra04375f

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