Synthesis and bioevaluation of thienopyrimidines bearing a pyrazoline unit as selective PI3Kα inhibitors

A series of thienopyrimidines containing a pyrazoline unit (4a–d, 7a–d and 13a–l) were designed and synthesized. The target compounds were evaluated for antiproliferative activity against A549, HepG2 and MCF-7 cancer cell lines. Among the twenty target compounds, most of them exhibited excellent ant...

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Detalles Bibliográficos
Autores principales: Lai, Luogen, Wang, Qinqin, Zhang, Binliang, Xiao, Zhen, Yang, Zunhua, Yang, Qi, Luo, Zixin, Zhu, Wufu, Xu, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072010/
https://www.ncbi.nlm.nih.gov/pubmed/35531514
http://dx.doi.org/10.1039/c9ra06192d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072010/
https://www.ncbi.nlm.nih.gov/pubmed/35531514
http://dx.doi.org/10.1039/c9ra06192d

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