Formal synthesis of (+)-lactacystin from l-serine

A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.

Detalles Bibliográficos
Autores principales: Bulman Page, Philip C., Goodyear, Ross L., Chan, Yohan, Slawin, Alexandra M. Z., Allin, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072140/
https://www.ncbi.nlm.nih.gov/pubmed/35531531
http://dx.doi.org/10.1039/c9ra07244f
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author Bulman Page, Philip C.
Goodyear, Ross L.
Chan, Yohan
Slawin, Alexandra M. Z.
Allin, Steven M.
author_facet Bulman Page, Philip C.
Goodyear, Ross L.
Chan, Yohan
Slawin, Alexandra M. Z.
Allin, Steven M.
author_sort Bulman Page, Philip C.
collection PubMed
description A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.
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spelling pubmed-90721402022-05-06 Formal synthesis of (+)-lactacystin from l-serine Bulman Page, Philip C. Goodyear, Ross L. Chan, Yohan Slawin, Alexandra M. Z. Allin, Steven M. RSC Adv Chemistry A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues. The Royal Society of Chemistry 2019-09-24 /pmc/articles/PMC9072140/ /pubmed/35531531 http://dx.doi.org/10.1039/c9ra07244f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Bulman Page, Philip C.
Goodyear, Ross L.
Chan, Yohan
Slawin, Alexandra M. Z.
Allin, Steven M.
Formal synthesis of (+)-lactacystin from l-serine
title Formal synthesis of (+)-lactacystin from l-serine
title_full Formal synthesis of (+)-lactacystin from l-serine
title_fullStr Formal synthesis of (+)-lactacystin from l-serine
title_full_unstemmed Formal synthesis of (+)-lactacystin from l-serine
title_short Formal synthesis of (+)-lactacystin from l-serine
title_sort formal synthesis of (+)-lactacystin from l-serine
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072140/
https://www.ncbi.nlm.nih.gov/pubmed/35531531
http://dx.doi.org/10.1039/c9ra07244f
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