Engineering an enhanced thrombin-based GLP-1 analog with long-lasting glucose-lowering and efficient weight reduction

Peptides are considered as potent therapeutic drugs primarily due to the exquisite potency and selectivity to targets. However, the development and clinical application of peptide drugs were severely limited by the poor in vivo lifespans. Here, we designed an improved small albumin-binding polypepti...

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Detalles Bibliográficos
Autores principales: Pan, Hongchao, Xie, Yini, Lu, Wenying, Chen, Yin, Lu, Zhao, Zhen, Jun, Wang, Weiwei, Shang, Anquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072222/
https://www.ncbi.nlm.nih.gov/pubmed/35529389
http://dx.doi.org/10.1039/c9ra06771j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072222/
https://www.ncbi.nlm.nih.gov/pubmed/35529389
http://dx.doi.org/10.1039/c9ra06771j

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