Cargando…

The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery

Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores. In this study, we demonstrate that the upregulated intestinal transporter (PCFT), which reaches a maximum of 12.3-fold expression in the intestinal epithelial cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jingyi, Zhang, Yaqi, Yu, Miaorong, Wang, Aohua, Qiu, Yu, Fan, Weiwei, Hovgaard, Lars, Yang, Mingshi, Li, Yiming, Wang, Rui, Li, Xiuying, Gan, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072239/ https://www.ncbi.nlm.nih.gov/pubmed/35530154 http://dx.doi.org/10.1016/j.apsb.2021.07.024

Ejemplares similares

Ligand-switchable nanoparticles resembling viral surface for sequential drug delivery and improved oral insulin therapy
por: Yang, Tiantian, et al.
Publicado: (2022)

Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake
por: Li, Xiuying, et al.
Publicado: (2011)

Rapid transport of germ-mimetic nanoparticles with dual conformational polyethylene glycol chains in biological tissues
por: Yang, Yiwei, et al.
Publicado: (2020)

Brain Uptake of Folate Forms in the Presence of Folate Receptor Alpha Antibodies in Young Rats: Folate and Antibody Distribution
por: Bobrowski-Khoury, Natasha, et al.
Publicado: (2023)

Mechanism of intestinal folate transport during folate deficiency in rodent model
por: Wani, Nissar Ahmad, et al.
Publicado: (2012)

Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors
por: Engevik, Melinda A., et al.
Publicado: (2019)

Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers
por: Yu, Miaorong, et al.
Publicado: (2018)

Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration
por: Shen, Hong, et al.
Publicado: (2016)

Increased brain uptake of pterostilbene loaded folate modified micellar delivery system
por: Wang, Yinan, et al.
Publicado: (2022)

Folate-modified Annonaceous acetogenins nanosuspensions and their improved antitumor efficacy
por: Hong, Jingyi, et al.
Publicado: (2017)

The Effect of Inflammatory Status on Butyrate and Folate Uptake by Tumoral (Caco-2) and Non-Tumoral (IEC-6) Intestinal Epithelial Cells
por: Couto, Mafalda R., et al.
Publicado: (2017)

Decitabine Sensitizes the Radioresistant Lung Adenocarcinoma to Pemetrexed Through Upregulation of Folate Receptor Alpha
por: Wang, Yuqing, et al.
Publicado: (2021)

Enhanced Uptake and Phototoxicity of C(60)@albumin Hybrids by Folate Bioconjugation
por: Cantelli, Andrea, et al.
Publicado: (2022)

Relationship of folate, vitamin B(12) and methylation of insulin-like growth factor-II in maternal and cord blood
por: Ba, Yue, et al.
Publicado: (2011)

Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults
por: Li, Jinchao, et al.
Publicado: (2017)

Evaluation of the novel folate receptor ligand [(18)F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis
por: Gent, Yoony YJ, et al.
Publicado: (2013)

Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells
por: Zhang, Qin, et al.
Publicado: (2019)

Ligand‐targeted polymerase chain reaction for the detection of folate receptor‐positive circulating tumour cells as a potential diagnostic biomarker for pancreatic cancer
por: Cheng, Hao, et al.
Publicado: (2020)

Development of Folate-Functionalized PEGylated Zein Nanoparticles for Ligand-Directed Delivery of Paclitaxel
por: Soe, Zar Chi, et al.
Publicado: (2019)

Role of miRNAs in regulation of SA-mediated upregulation of genes involved in folate and methionine metabolism in foxtail millet
por: Hou, Siyu, et al.
Publicado: (2022)

Effects of ligand distribution on receptor-diffusion-mediated cellular uptake of nanoparticles
por: Li, Long, et al.
Publicado: (2017)

Site-specific glycoproteomic analysis revealing increased core-fucosylation on FOLR1 enhances folate uptake capacity of HCC cells to promote EMT
por: Jia, Li, et al.
Publicado: (2021)

Folate intake, serum folate levels, and prostate cancer risk: a meta-analysis of prospective studies
por: Wang, Rong, et al.
Publicado: (2014)

Priming with Retinoic Acid, an Active Metabolite of Vitamin A, Increases Vitamin A Uptake in the Small Intestine of Neonatal Rats
por: Li, Yaqi, et al.
Publicado: (2021)

Confocal microscopy visualization of antifolate uptake by the reduced folate carrier in human leukaemic cells.
por: Jolivet, J., et al.
Publicado: (1997)

Improving the uptake of preconception care and periconceptional folate supplementation: what do women think?
por: Mazza, Danielle, et al.
Publicado: (2010)

Clinical Significance of Folate Receptor-positive Circulating Tumor Cells Detected by Ligand-targeted Polymerase Chain Reaction in Lung Cancer
por: Wang, Lin, et al.
Publicado: (2017)

Selenite Uptake and Transformation in Rice Seedlings (Oryza sativa L.): Response to Phosphorus Nutrient Status
por: Wang, Yaqi, et al.
Publicado: (2020)

Ginsenoside Rc Ameliorates Endothelial Insulin Resistance via Upregulation of Angiotensin-Converting Enzyme 2
por: Wang, Yaozhen, et al.
Publicado: (2021)

Lactobacillus acidophilus and Bifidobacterium longum supernatants upregulate the serotonin transporter expression in intestinal epithelial cells
por: Cao, Ya-Nan, et al.
Publicado: (2018)

A Complex Relationship: Dietary Folate, Arsenic Metabolism, and Insulin Resistance in Mice
por: Schmidt, Silke
Publicado: (2019)

Zymosan-A promotes the regeneration of intestinal stem cells by upregulating ASCL2
por: Du, Jicong, et al.
Publicado: (2022)

Targeting folate receptor β positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex
por: Tie, Yan, et al.
Publicado: (2020)

Clinic study on macular epiretinal membrane in patients under the age of 40 years
por: Wang, Nan, et al.
Publicado: (2023)

Effects of antiepileptic drugs on the serum folate and vitamin B12 in various epileptic patients
por: Huang, Hong-Li, et al.
Publicado: (2016)

Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes
por: Du, Zhi-Qiang, et al.
Publicado: (2022)

High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities
por: Miner, Maxwell W. G., et al.
Publicado: (2023)

Vitamin D Improves Intestinal Barrier Function in Cirrhosis Rats by Upregulating Heme Oxygenase-1 Expression
por: Wang, Peng-fei, et al.
Publicado: (2019)

Effect of paternal folate deficiency on placental folate content and folate receptor α expression in rats
por: Kim, Hye Won, et al.
Publicado: (2011)

Efficient capture of circulating tumor cells with low molecular weight folate receptor-specific ligands
por: Hu, Yingwen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j9toidvqi8c4j7mf0jsl9a6lue