Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain

Soluble epoxide hydrolase (sEH) is related to arachidonic acid cascade and is over-expressed in a variety of diseases, making sEH an attractive target for the treatment of pain as well as inflammatory-related diseases. A new series of memantyl urea derivatives as potent sEH inhibitors was obtained u...

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Detalles Bibliográficos
Autores principales: Du, Fangyu, Cao, Ruolin, Chen, Lu, Sun, Jianwen, Shi, Yajie, Fu, Yang, Hammock, Bruce D., Zheng, Zhonghui, Liu, Zhongbo, Chen, Guoliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072249/
https://www.ncbi.nlm.nih.gov/pubmed/35530144
http://dx.doi.org/10.1016/j.apsb.2021.09.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072249/
https://www.ncbi.nlm.nih.gov/pubmed/35530144
http://dx.doi.org/10.1016/j.apsb.2021.09.018

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