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Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain

Soluble epoxide hydrolase (sEH) is related to arachidonic acid cascade and is over-expressed in a variety of diseases, making sEH an attractive target for the treatment of pain as well as inflammatory-related diseases. A new series of memantyl urea derivatives as potent sEH inhibitors was obtained u...

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Detalles Bibliográficos
Autores principales:	Du, Fangyu, Cao, Ruolin, Chen, Lu, Sun, Jianwen, Shi, Yajie, Fu, Yang, Hammock, Bruce D., Zheng, Zhonghui, Liu, Zhongbo, Chen, Guoliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072249/ https://www.ncbi.nlm.nih.gov/pubmed/35530144 http://dx.doi.org/10.1016/j.apsb.2021.09.018

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