Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release

A large hexanucleotide repeat expansion in the C9ORF72 gene is the most prevalent cause of amyotrophic lateral sclerosis (ALS). To better understand neuronal dysfunction during ALS progression, we studied motor neuron (MN) cultures derived from iPSC lines generated from C9ORF72 (C9) expansion carrie...

Descripción completa

Detalles Bibliográficos
Autores principales: Burley, Sarah, Beccano-Kelly, Dayne A., Talbot, Kevin, Llana, Oscar Cordero, Wade-Martins, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072315/
https://www.ncbi.nlm.nih.gov/pubmed/35513421
http://dx.doi.org/10.1038/s41598-022-09751-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072315/
https://www.ncbi.nlm.nih.gov/pubmed/35513421
http://dx.doi.org/10.1038/s41598-022-09751-3

Ejemplares similares