Cargando…

Encapsulation of echinomycin in cyclodextrin inclusion complexes into liposomes: in vitro anti-proliferative and anti-invasive activity in glioblastoma

Echinomycin, a DNA bis-intercalator peptide, belongs to the family of quinoxaline antibiotics. Echinomycin exhibits potent antitumor and antimicrobial activity. However, it is highly water insoluble and suffers from low bioavailability and unwanted side effects. Therefore, developing new formulation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alshaer, Walhan, Zraikat, Manar, Amer, Amer, Nsairat, Hamdi, Lafi, Zainab, Alqudah, Dana A., Al Qadi, Enas, Alsheleh, Tasneem, Odeh, Fadwa, Alkaraki, Arwa, Zihlif, Malek, Bustanji, Yasser, Fattal, Elias, Awidi, Abdalla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072562/ https://www.ncbi.nlm.nih.gov/pubmed/35529392 http://dx.doi.org/10.1039/c9ra05636j

Ejemplares similares

Aptamer-functionalized pH-sensitive liposomes for a selective delivery of echinomycin into cancer cells
por: Lafi, Zainab, et al.
Publicado: (2021)

Remote loading of curcumin-in-modified β-cyclodextrins into liposomes using a transmembrane pH gradient
por: Odeh, Fadwa, et al.
Publicado: (2019)

Grafting of anti-nucleolin aptamer into preformed and remotely loaded liposomes through aptamer-cholesterol post-insertion
por: Nsairat, Hamdi, et al.
Publicado: (2020)

Synthesis of Mono-Amino Substituted γ-CD: Host–Guest Complexation and In Vitro Cytotoxicity Investigation
por: Odeh, Fadwa, et al.
Publicado: (2022)

Liposomes: structure, composition, types, and clinical applications()
por: Nsairat, Hamdi, et al.
Publicado: (2022)

Cinnamaldehyde–cucurbituril complex: investigation of loading efficiency and its role in enhancing cinnamaldehyde in vitro anti-tumor activity
por: Al Tbakhi, Bayan, et al.
Publicado: (2022)

Aptamers Chemistry: Chemical Modifications and Conjugation Strategies
por: Odeh, Fadwa, et al.
Publicado: (2019)

Downregulation of STAT3, β-Catenin, and Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin
por: Alshaer, Walhan, et al.
Publicado: (2019)

Lipid nanostructures for targeting brain cancer
por: Nsairat, Hamdi, et al.
Publicado: (2021)

Quality by Design Approach in Liposomal Formulations: Robust Product Development
por: Alshaer, Walhan, et al.
Publicado: (2022)

Aptamer-Aptamer Chimera for Targeted Delivery and ATP-Responsive Release of Doxorubicin into Cancer Cells
por: Esawi, Ezaldeen, et al.
Publicado: (2021)

Effects of cyclic acute and chronic hypoxia on the expression levels of metabolism related genes in a pancreatic cancer cell line
por: Obeidat, Nour M., et al.
Publicado: (2022)

Preparation, characterization, and biological activity study of thymoquinone-cucurbit[7]uril inclusion complex
por: Alrawashdeh, Lubna, et al.
Publicado: (2022)

Selection and targeting of EpCAM protein by ssDNA aptamer
por: Alshaer, Walhan, et al.
Publicado: (2017)

Co-encapsulation of thymoquinone with docetaxel enhances the encapsulation efficiency into PEGylated liposomes and the chemosensitivity of MCF7 breast cancer cells to docetaxel
por: Odeh, Fadwa, et al.
Publicado: (2019)

Synergistic combination of doxorubicin with hydralazine, and disulfiram against MCF-7 breast cancer cell line
por: Lafi, Zainab, et al.
Publicado: (2023)

An In Vitro Comparison of Anti-Tumoral Potential of Wharton’s Jelly and Bone Marrow Mesenchymal Stem Cells Exhibited by Cell Cycle Arrest in Glioma Cells (U87MG)
por: Aslam, Nazneen, et al.
Publicado: (2021)

Correction: Selection and targeting of EpCAM protein by ssDNA aptamer
por: Alshaer, Walhan, et al.
Publicado: (2018)

Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects
por: Satange, Roshan, et al.
Publicado: (2023)

1,4-Naphthoquinone Is a Potent Inhibitor of IRAK1 Kinases and the Production of Inflammatory Cytokines in THP-1 Differentiated Macrophages
por: Mahmoud, Ismail Sami, et al.
Publicado: (2021)

Synthesis, Characterization, and Assessment of Anti-Cancer Potential of ZnO Nanoparticles in an In Vitro Model of Breast Cancer
por: Aljabali, Alaa A. A., et al.
Publicado: (2022)

Biological Performance of Primary Dental Pulp Stem Cells Treated with Gold Nanoparticles
por: Abuarqoub, Duaa, et al.
Publicado: (2023)

Editorial: Anti-cancer drug delivery: lipid-based nanoparticles
por: Alkilany, Alaaldin M., et al.
Publicado: (2023)

Anti-oncogenic activities exhibited by paracrine factors of MSCs can be mediated by modulation of KITLG and DKK1 genes in glioma SCs in vitro
por: Aslam, Nazneen, et al.
Publicado: (2020)

Echinomycin as a promising therapeutic agent against KSHV-related malignancies
por: Chen, Jungang, et al.
Publicado: (2023)

Effects of echinomycin on endothelin-2 expression and ovulation in immature rats primed with gonadotropins
por: Wang, Zhengchao, et al.
Publicado: (2012)

Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex
por: Wu, Pei-Ching, et al.
Publicado: (2018)

The Immunomodulatory and Regenerative Effect of Biodentine™ on Human THP-1 Cells and Dental Pulp Stem Cells: In Vitro Study
por: Abuarqoub, Duaa, et al.
Publicado: (2022)

Formulating co-loaded nanoliposomes with gallic acid and quercetin for enhanced cancer therapy
por: Al-Samydai, Ali, et al.
Publicado: (2023)

Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner
por: Yamaguchi, Junna, et al.
Publicado: (2017)

Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo
por: Thomas, Alexandra, et al.
Publicado: (2020)

Structural and functional analyses of the echinomycin resistance conferring protein Ecm16 from Streptomyces lasalocidi
por: Gade, Priyanka, et al.
Publicado: (2023)

Screening the RFX6-DNA binding domain for potential genetic variants in patients with type 2 diabetes
por: Mahmoud, Ismail Sami, et al.
Publicado: (2019)

Therapeutic Targeting of TP53-mutated Acute Myeloid Leukemia by Inhibiting HIF-1α with Echinomycin
por: Wang, Yin, et al.
Publicado: (2020)

The UvrA‐like protein Ecm16 requires ATPase activity to render resistance against echinomycin
por: Erlandson, Amanda, et al.
Publicado: (2022)

Biosynthesis of gold nanoparticles using leaf extract of Dittrichia viscosa and in vivo assessment of its anti-diabetic efficacy
por: Ayyoub, Sanaa, et al.
Publicado: (2022)

In Vitro Characterization of Echinomycin Biosynthesis: Formation and Hydroxylation of L-Tryptophanyl-S-Enzyme and Oxidation of (2S,3S) β-Hydroxytryptophan
por: Zhang, Chen, et al.
Publicado: (2013)

Echinomycin did not affect the safety of fracture healing: an experimental pilot study on a murine femur fracture model
por: Jentzsch, Thorsten, et al.
Publicado: (2016)

Characterization of Streptomyces sp. LS462 with high productivity of echinomycin, a potent antituberculosis and synergistic antifungal antibiotic
por: Chen, Caixia, et al.
Publicado: (2021)

GSDM gene polymorphisms regulate the IgE level in asthmatic patients
por: Imraish, Amer, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_udj6fsttiaaedij2f2se1u99v7