Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents

Combinatorial synthesis of (E)-β-trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates in DMSO under metal-free conditions at room temperature. These compounds are evaluated in several assays against different tumor cells. Some hits...

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Detalles Bibliográficos
Autores principales: Tang, Haosha, Kuang, Yunyan, Zeng, Julan, Li, Xiaofang, Zhou, Wei, Lu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072619/
https://www.ncbi.nlm.nih.gov/pubmed/35527921
http://dx.doi.org/10.1039/c9ra06368d
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author Tang, Haosha
Kuang, Yunyan
Zeng, Julan
Li, Xiaofang
Zhou, Wei
Lu, Yuan
author_facet Tang, Haosha
Kuang, Yunyan
Zeng, Julan
Li, Xiaofang
Zhou, Wei
Lu, Yuan
author_sort Tang, Haosha
collection PubMed
description Combinatorial synthesis of (E)-β-trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates in DMSO under metal-free conditions at room temperature. These compounds are evaluated in several assays against different tumor cells. Some hits are identified against ES-2, HO-8910, and K562.
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spelling pubmed-90726192022-05-06 Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents Tang, Haosha Kuang, Yunyan Zeng, Julan Li, Xiaofang Zhou, Wei Lu, Yuan RSC Adv Chemistry Combinatorial synthesis of (E)-β-trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates in DMSO under metal-free conditions at room temperature. These compounds are evaluated in several assays against different tumor cells. Some hits are identified against ES-2, HO-8910, and K562. The Royal Society of Chemistry 2019-10-03 /pmc/articles/PMC9072619/ /pubmed/35527921 http://dx.doi.org/10.1039/c9ra06368d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Tang, Haosha
Kuang, Yunyan
Zeng, Julan
Li, Xiaofang
Zhou, Wei
Lu, Yuan
Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents
title Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents
title_full Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents
title_fullStr Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents
title_full_unstemmed Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents
title_short Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents
title_sort combinatorial synthesis and biological evaluations of (e)-β-trifluoromethyl vinylsulfones as antitumor agents
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072619/
https://www.ncbi.nlm.nih.gov/pubmed/35527921
http://dx.doi.org/10.1039/c9ra06368d
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