Declining Levels and Bioavailability of IGF-I in Cardiovascular Aging Associate With QT Prolongation–Results From the 1946 British Birth Cohort

BACKGROUND: As people age, circulating levels of insulin-like growth factors (IGFs) and IGF binding protein 3 (IGFBP-3) decline. In rat cardiomyocytes, IGF-I has been shown to regulate sarcolemmal potassium channel activity and late sodium current thus impacting cardiac repolarization and the heart...

Descripción completa

Detalles Bibliográficos
Autores principales: Charalambous, Christos, Moon, James C., Holly, Jeff M. P., Chaturvedi, Nishi, Hughes, Alun D., Captur, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072634/
https://www.ncbi.nlm.nih.gov/pubmed/35528832
http://dx.doi.org/10.3389/fcvm.2022.863988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072634/
https://www.ncbi.nlm.nih.gov/pubmed/35528832
http://dx.doi.org/10.3389/fcvm.2022.863988

Ejemplares similares