Novel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography

The VP8* domain of spike protein VP4 in group A and C rotaviruses, which cause epidemic gastroenteritis in children, exhibits a conserved galectin-like fold for recognizing glycans during cell entry. In group B rotavirus, which causes significant diarrheal outbreaks in adults, the VP8* domain (VP8*B...

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Detalles Bibliográficos
Autores principales: Hu, Liya, Salmen, Wilhelm, Sankaran, Banumathi, Lasanajak, Yi, Smith, David F., Crawford, Sue E., Estes, Mary K., Prasad, B. V. Venkataram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072675/
https://www.ncbi.nlm.nih.gov/pubmed/35513489
http://dx.doi.org/10.1038/s42003-022-03357-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072675/
https://www.ncbi.nlm.nih.gov/pubmed/35513489
http://dx.doi.org/10.1038/s42003-022-03357-1

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