Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases

Ivermectin (IVM), an avermectin-derivative anthelmintic, specifically binds to glutamate-gated chloride ion channels (GluCls), causing paralysis in invertebrates. IVM also exhibits other biological activities such as Wnt/β-catenin pathway inhibition in vertebrates that do not possess GluCls. This st...

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Detalles Bibliográficos
Autores principales: Yonezawa, Honami, Ikeda, Akari, Takahashi, Ryo, Endo, Haruka, Sugawara, Yasuyo, Goto, Mikako, Kanno, Mirute, Ogawa, Sosuke, Nakamura, Karin, Ujiie, Haruki, Iwatsuki, Masato, Hirose, Tomoyasu, Sunazuka, Toshiaki, Uehara, Yoshimasa, Nishiya, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072907/
https://www.ncbi.nlm.nih.gov/pubmed/35530256
http://dx.doi.org/10.1016/j.isci.2022.103912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072907/
https://www.ncbi.nlm.nih.gov/pubmed/35530256
http://dx.doi.org/10.1016/j.isci.2022.103912

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