Suzuki coupling-based synthesis of VATPase inhibitor archazolid natural product derived fragments

An archazolid natural product fragment that displays dose-dependent inhibition of the vacuolar-type ATPase (VATPase) has been synthesized by a high-yielding Suzuki coupling of two complex subunits. Similarly, a further simplified fragment was prepared and evaluated for VATPase inhibitory activity. T...

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Detalles Bibliográficos
Autores principales: Vincent, Cooper T., Long, Evan T., Jones, Holly C., Young, Jeffrey C., Spiegel, P. Clint, O'Neil, Gregory W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072946/
https://www.ncbi.nlm.nih.gov/pubmed/35530773
http://dx.doi.org/10.1039/c9ra07050h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072946/
https://www.ncbi.nlm.nih.gov/pubmed/35530773
http://dx.doi.org/10.1039/c9ra07050h

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