A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring

A new family of anticancer compounds has been derived from oxaliplatin by inserting a double-bond between carbons 4 and 5 of the 1,2-diaminocyclohexane ring. Testing against a panel of human tumour cell lines including cervical (A431), ovarian (2008), and colon carcinomas (HCT-15 and LoVo), and two...

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Detalles Bibliográficos
Autores principales: Papadia, Paride, Gandin, Valentina, Barbanente, Alessandra, Ruello, Alessandro G., Marzano, Cristina, Micoli, Katia, Hoeschele, James D., Natile, Giovanni, Margiotta, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072990/
https://www.ncbi.nlm.nih.gov/pubmed/35529760
http://dx.doi.org/10.1039/c9ra07760j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072990/
https://www.ncbi.nlm.nih.gov/pubmed/35529760
http://dx.doi.org/10.1039/c9ra07760j

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