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Sapitinib: reactive intermediates and bioactivation pathways characterized by LC-MS/MS
Sapitinib (AZD8931, SAP) is an epidermal growth factor receptor (EGFR) family (pan-erbB) tyrosine kinase inhibitor. In multiple tumor cell lines, SAP has been shown to be a much more potent inhibitor of EGF-driven cellular proliferation than gefitinib. In this in vitro metabolic study, we tested the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society of Chemistry
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073192/ https://www.ncbi.nlm.nih.gov/pubmed/35529145 http://dx.doi.org/10.1039/c9ra03926k |