Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone

Alcohol Use Disorder (AUD) is characterized by loss of control over drinking. Behavioral control is mediated, in part, by cortical dopamine signaling. Inhibition of catechol-O-methyltransferase (COMT), the enzyme primarily responsible for cortical dopamine inactivation, may increase cortical dopamin...

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Detalles Bibliográficos
Autores principales: Schacht, Joseph P., Yeongbin Im, Hoffman, Michaela, Voronin, Konstantin E., Book, Sarah W., Anton, Raymond F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073504/
https://www.ncbi.nlm.nih.gov/pubmed/35523943
http://dx.doi.org/10.1038/s41386-022-01335-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073504/
https://www.ncbi.nlm.nih.gov/pubmed/35523943
http://dx.doi.org/10.1038/s41386-022-01335-z

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