Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability

The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody–drug conjugates (ADCs) with in vivo efficacy and tolerability is reported. Detailed structural characterisation of the synthesised ADCs was first conducted followed by in vitro and in vivo evaluation of the ADCs’ abili...

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Detalles Bibliográficos
Autores principales: Walsh, Stephen J., Omarjee, Soleilmane, Dannheim, Friederike M., Couturier, Dominique-Laurent, Bexheti, Dorentina, Mendil, Lee, Cronshaw, Gemma, Fewster, Toby, Gregg, Charlotte, Brodie, Cara, Miller, Jodi L., Houghton, Richard, Carroll, Jason S., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073851/
https://www.ncbi.nlm.nih.gov/pubmed/35044383
http://dx.doi.org/10.1039/d1cc06766d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073851/
https://www.ncbi.nlm.nih.gov/pubmed/35044383
http://dx.doi.org/10.1039/d1cc06766d

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