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Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability
The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody–drug conjugates (ADCs) with in vivo efficacy and tolerability is reported. Detailed structural characterisation of the synthesised ADCs was first conducted followed by in vitro and in vivo evaluation of the ADCs’ abili...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073851/ https://www.ncbi.nlm.nih.gov/pubmed/35044383 http://dx.doi.org/10.1039/d1cc06766d |
| _version_ | 1784701378792259584 |
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| author | Walsh, Stephen J. Omarjee, Soleilmane Dannheim, Friederike M. Couturier, Dominique-Laurent Bexheti, Dorentina Mendil, Lee Cronshaw, Gemma Fewster, Toby Gregg, Charlotte Brodie, Cara Miller, Jodi L. Houghton, Richard Carroll, Jason S. Spring, David R. |
| author_facet | Walsh, Stephen J. Omarjee, Soleilmane Dannheim, Friederike M. Couturier, Dominique-Laurent Bexheti, Dorentina Mendil, Lee Cronshaw, Gemma Fewster, Toby Gregg, Charlotte Brodie, Cara Miller, Jodi L. Houghton, Richard Carroll, Jason S. Spring, David R. |
| author_sort | Walsh, Stephen J. |
| collection | PubMed |
| description | The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody–drug conjugates (ADCs) with in vivo efficacy and tolerability is reported. Detailed structural characterisation of the synthesised ADCs was first conducted followed by in vitro and in vivo evaluation of the ADCs’ ability to safely and selectively eradicate target-positive tumours. |
| format | Online Article Text |
| id | pubmed-9073851 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | The Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90738512022-05-27 Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability Walsh, Stephen J. Omarjee, Soleilmane Dannheim, Friederike M. Couturier, Dominique-Laurent Bexheti, Dorentina Mendil, Lee Cronshaw, Gemma Fewster, Toby Gregg, Charlotte Brodie, Cara Miller, Jodi L. Houghton, Richard Carroll, Jason S. Spring, David R. Chem Commun (Camb) Chemistry The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody–drug conjugates (ADCs) with in vivo efficacy and tolerability is reported. Detailed structural characterisation of the synthesised ADCs was first conducted followed by in vitro and in vivo evaluation of the ADCs’ ability to safely and selectively eradicate target-positive tumours. The Royal Society of Chemistry 2022-01-13 /pmc/articles/PMC9073851/ /pubmed/35044383 http://dx.doi.org/10.1039/d1cc06766d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
| spellingShingle | Chemistry Walsh, Stephen J. Omarjee, Soleilmane Dannheim, Friederike M. Couturier, Dominique-Laurent Bexheti, Dorentina Mendil, Lee Cronshaw, Gemma Fewster, Toby Gregg, Charlotte Brodie, Cara Miller, Jodi L. Houghton, Richard Carroll, Jason S. Spring, David R. Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability |
| title | Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability |
| title_full | Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability |
| title_fullStr | Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability |
| title_full_unstemmed | Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability |
| title_short | Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability |
| title_sort | divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073851/ https://www.ncbi.nlm.nih.gov/pubmed/35044383 http://dx.doi.org/10.1039/d1cc06766d |
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