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Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability
The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody–drug conjugates (ADCs) with in vivo efficacy and tolerability is reported. Detailed structural characterisation of the synthesised ADCs was first conducted followed by in vitro and in vivo evaluation of the ADCs’ abili...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073851/ https://www.ncbi.nlm.nih.gov/pubmed/35044383 http://dx.doi.org/10.1039/d1cc06766d |