Design, synthesis and evaluation of novel, branched trident small interfering RNA nanostructures for sequence-specific RNAi activity

Small interfering RNAs (siRNAs) are potential candidates for gene regulation with efficient activity, but off-target effects and limited systemic delivery. Herein, we report the design and synthesis of the branched siRNA nanostructures with highly improved resistance against exonucleases. Also, thes...

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Detalles Bibliográficos
Autores principales: Chandela, Akash, Ueno, Yoshihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073863/
https://www.ncbi.nlm.nih.gov/pubmed/35529995
http://dx.doi.org/10.1039/c9ra08071f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073863/
https://www.ncbi.nlm.nih.gov/pubmed/35529995
http://dx.doi.org/10.1039/c9ra08071f

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