Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim

[Image: see text] The identification and study of supramolecular synthons is a fundamental task in the design of pharmaceutical cocrystals. The malaria drug pyrimethamine (pyr) and the antibiotic trimethoprim (tmp) are both 2,4-diaminopyrimidine derivatives, providing the same C–NH(2)/N=C/C–NH(2) an...

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Detalles Bibliográficos
Autores principales: Alaa Eldin Refat, Lamis, O’Malley, Ciaran, Simmie, John M., McArdle, Patrick, Erxleben, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073935/
https://www.ncbi.nlm.nih.gov/pubmed/35529062
http://dx.doi.org/10.1021/acs.cgd.2c00035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073935/
https://www.ncbi.nlm.nih.gov/pubmed/35529062
http://dx.doi.org/10.1021/acs.cgd.2c00035

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