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High-Resolution Hydrogen–Deuterium Protection Factors from Sparse Mass Spectrometry Data Validated by Nuclear Magnetic Resonance Measurements

[Image: see text] Experimental measurement of time-dependent spontaneous exchange of amide protons with deuterium of the solvent provides information on the structure and dynamical structural variation in proteins. Two experimental techniques are used to probe the exchange: NMR, which relies on diff...

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Detalles Bibliográficos
Autores principales: Stofella, Michele, Skinner, Simon P., Sobott, Frank, Houwing-Duistermaat, Jeanine, Paci, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074100/
https://www.ncbi.nlm.nih.gov/pubmed/35385652
http://dx.doi.org/10.1021/jasms.2c00005