Solubilization, purification, and ligand binding characterization of G protein-coupled receptor SMO in native membrane bilayer using styrene maleic acid copolymer

Smoothened (SMO) protein is a member of the G protein-coupled receptor (GPCR) family that is involved in the Hedgehog (Hh) signaling pathway. It is a putative target for treating various cancers, including medulloblastoma and basal cell carcinoma (BCC). Characterizing membrane proteins such as SMO i...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Lina, Zhao, Hongxin, Wang, Yizhuo, Yu, Chuandi, Liu, Juanjuan, Li, Ling, Li, Zehua, Zhang, Jin, Dai, Han, Wang, Junfeng, Zhu, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074879/
https://www.ncbi.nlm.nih.gov/pubmed/35529497
http://dx.doi.org/10.7717/peerj.13381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074879/
https://www.ncbi.nlm.nih.gov/pubmed/35529497
http://dx.doi.org/10.7717/peerj.13381

Ejemplares similares