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Solubilization, purification, and ligand binding characterization of G protein-coupled receptor SMO in native membrane bilayer using styrene maleic acid copolymer

Smoothened (SMO) protein is a member of the G protein-coupled receptor (GPCR) family that is involved in the Hedgehog (Hh) signaling pathway. It is a putative target for treating various cancers, including medulloblastoma and basal cell carcinoma (BCC). Characterizing membrane proteins such as SMO i...

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Detalles Bibliográficos
Autores principales:	Zhu, Lina, Zhao, Hongxin, Wang, Yizhuo, Yu, Chuandi, Liu, Juanjuan, Li, Ling, Li, Zehua, Zhang, Jin, Dai, Han, Wang, Junfeng, Zhu, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2022
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074879/ https://www.ncbi.nlm.nih.gov/pubmed/35529497 http://dx.doi.org/10.7717/peerj.13381

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