ZFC3H1 and U1-70K promote the nuclear retention of mRNAs with 5′ splice site motifs within nuclear speckles

Quality control of mRNA represents an important regulatory mechanism for gene expression in eukaryotes. One component of this quality control is the nuclear retention and decay of misprocessed RNAs. Previously, we demonstrated that mature mRNAs containing a 5′ splice site (5′SS) motif, which is typi...

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Detalles Bibliográficos
Autores principales: Lee, Eliza S., Smith, Harrison W., Wolf, Eric J., Guvenek, Aysegul, Wang, Yifan E., Emili, Andrew, Tian, Bin, Palazzo, Alexander F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074902/
https://www.ncbi.nlm.nih.gov/pubmed/35351812
http://dx.doi.org/10.1261/rna.079104.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074902/
https://www.ncbi.nlm.nih.gov/pubmed/35351812
http://dx.doi.org/10.1261/rna.079104.122

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