Ligands with polyfluorophenyl moieties promote a local structural rearrangement in the Spinach2 and Broccoli aptamers that increases ligand affinities

The interaction of nucleic acids with their molecular targets often involves structural reorganization that may traverse a complex folding landscape. With the more recent recognition that many RNAs, both coding and noncoding, may regulate cellular activities by interacting with target molecules, it...

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Detalles Bibliográficos
Autores principales: Anisuzzaman, Sharif, Geraskin, Ivan M., Ilgu, Muslum, Bendickson, Lee, Kraus, George A., Nilsen-Hamilton, Marit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074905/
https://www.ncbi.nlm.nih.gov/pubmed/35351813
http://dx.doi.org/10.1261/rna.079005.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074905/
https://www.ncbi.nlm.nih.gov/pubmed/35351813
http://dx.doi.org/10.1261/rna.079005.121

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