SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes

BACKGROUND: Isolated loss‐of‐function single nucleotide polymorphisms (SNPs) for SIRT3 (a mitochondrial deacetylase) and UCP2 (an atypical uncoupling protein enabling mitochondrial calcium entry) have been associated with both pulmonary arterial hypertension (PAH) and insulin resistance, but their c...

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Detalles Bibliográficos
Autores principales: Zhang, Yongneng, Zervopoulos, Sotirios D., Boukouris, Aristeidis E., Lorenzana‐Carrillo, Maria Areli, Saleme, Bruno, Webster, Linda, Liu, Yongsheng, Haromy, Alois, Tabatabaei Dakhili, Seyed Amirhossein, Ussher, John R., Sutendra, Gopinath, Michelakis, Evangelos D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075406/
https://www.ncbi.nlm.nih.gov/pubmed/34719264
http://dx.doi.org/10.1161/JAHA.120.020451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075406/
https://www.ncbi.nlm.nih.gov/pubmed/34719264
http://dx.doi.org/10.1161/JAHA.120.020451

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