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Allylation of isatin-derived N-Boc-hydrazones followed by Pd-catalyzed carboamination reaction: an entry to 3-spiro-pyrazolidyl-oxindoles

The indium-mediated allylation of novel 3-(2-Boc-hydrazono)indolin-2-one derivatives, followed by a palladium-catalysed carboamination reaction, is described to afford unprecedented spirocyclic oxindoles in good yields. The method provides an efficient access to both cis and trans diastereoisomers o...

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Detalles Bibliográficos
Autores principales: Gazzotti, Stefano, Manenti, Marco, Lo Presti, Leonardo, Silvani, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075743/
https://www.ncbi.nlm.nih.gov/pubmed/35541813
http://dx.doi.org/10.1039/c9ra07712j