Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation

Both the kinase MET and the WNT signaling pathway are attractive targets in cancer therapy, and synergistic effects have previously been observed in animal models upon simultaneous inhibition. A strategy towards a designed multiple ligand of MET and WNT signaling is pursued based on the two hetero b...

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Detalles Bibliográficos
Autores principales: Lien, Vegard Torp, Kristiansen, Margrethe Konstanse, Pettersen, Solveig, Haugen, Mads Haugland, Olberg, Dag Erlend, Waaler, Jo, Klaveness, Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075752/
https://www.ncbi.nlm.nih.gov/pubmed/35539091
http://dx.doi.org/10.1039/c9ra08954c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075752/
https://www.ncbi.nlm.nih.gov/pubmed/35539091
http://dx.doi.org/10.1039/c9ra08954c

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