Cargando…
GPI0363 inhibits the interaction of RNA polymerase with DNA in Staphylococcus aureus
We previously reported a therapeutically effective spiro-heterocyclic compound, GPI0363, that inhibits the transcription of Staphylococcus aureus via the primary sigma factor of RNA polymerase, SigA. Here, we demonstrated that GPI0363 shares no cross-resistance with the clinically used RNA polymeras...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075815/ https://www.ncbi.nlm.nih.gov/pubmed/35541796 http://dx.doi.org/10.1039/c9ra06844a |