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GPI0363 inhibits the interaction of RNA polymerase with DNA in Staphylococcus aureus

We previously reported a therapeutically effective spiro-heterocyclic compound, GPI0363, that inhibits the transcription of Staphylococcus aureus via the primary sigma factor of RNA polymerase, SigA. Here, we demonstrated that GPI0363 shares no cross-resistance with the clinically used RNA polymeras...

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Detalles Bibliográficos
Autores principales:	Paudel, Atmika, Panthee, Suresh, Hamamoto, Hiroshi, Sekimizu, Kazuhisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075815/ https://www.ncbi.nlm.nih.gov/pubmed/35541796 http://dx.doi.org/10.1039/c9ra06844a

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