HSP90 N‐terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2‐driven breast cancer progression

AIMS: MORC family CW‐type zinc finger 2 (MORC2), a GHKL‐type ATPase, is aberrantly upregulated in multiple types of human tumors with profound effects on cancer aggressiveness, therapeutic resistance, and clinical outcome, thus making it an attractive drug target for anticancer therapy. However, the...

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Detalles Bibliográficos
Autores principales: Yang, Fan, Sun, Rui, Hou, Zeng, Zhang, Fang‐Lin, Xiao, Yi, Yang, Yun‐Song, Yang, Shao‐Ying, Xie, Yi‐Fan, Liu, Ying‐Ying, Luo, Cheng, Liu, Guang‐Yu, Shao, Zhi‐Min, Li, Da‐Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076019/
https://www.ncbi.nlm.nih.gov/pubmed/35522895
http://dx.doi.org/10.1002/ctm2.825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076019/
https://www.ncbi.nlm.nih.gov/pubmed/35522895
http://dx.doi.org/10.1002/ctm2.825

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