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A simple and robust reporter gene assay for measuring the bioactivity of anti-RANKL therapeutic antibodies

RANKL (receptor activator of nuclear factor κB ligand) plays a key role in the differentiation, activation and survival of osteoclasts. Denosumab, which targets RANKL, is approved for osteoporosis or bone loss that has a high risk for fracture and bone metastases from solid tumors. Bioactivity deter...

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Detalles Bibliográficos
Autores principales: Yu, Chuanfei, Wang, Lan, Ni, Yongbo, Wang, Junzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076180/
https://www.ncbi.nlm.nih.gov/pubmed/35542634
http://dx.doi.org/10.1039/c9ra07328k