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Novel entry to the synthesis of (S)- and (R)-5-methoxycarbonylhydroxymethyluridines – a diastereomeric pair of wobble tRNA nucleosides
Two novel methods for the preparation of the virtually equimolar mixtures of (S)- and (R)-diastereomers of 5-methoxycarbonylhydroxymethyluridine (mchm(5)U) have been developed. The first method involved α-hydroxylation of a 5-malonate ester derivative of uridine (5) with SeO(2), followed by transfor...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076229/ https://www.ncbi.nlm.nih.gov/pubmed/35542686 http://dx.doi.org/10.1039/c9ra08548c |