Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53

Cancer cells often experience high basal levels of DNA replication stress (RS), for example due to hyperactivation of oncoproteins like MYC or RAS. Therefore, cancer cells are considered to be sensitive to drugs that exacerbate the level of RS or block the intra S-phase checkpoint. Consequently, RS-...

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Detalles Bibliográficos
Autores principales: Segeren, Hendrika A., van Liere, Elsbeth A., Riemers, Frank M., de Bruin, Alain, Westendorp, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076537/
https://www.ncbi.nlm.nih.gov/pubmed/35393546
http://dx.doi.org/10.1038/s41388-022-02291-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076537/
https://www.ncbi.nlm.nih.gov/pubmed/35393546
http://dx.doi.org/10.1038/s41388-022-02291-0

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